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We found a positive test in 14 of 100 patients, only two of whom had definite Creutzfeldt-Jakob disease. Positive results were found in patients with various degenerative dementias, including AD (4), frontotemporal dementia (2), and dementi a with Lewy body (1), and in patients with vascular dementia (1), carcinomatous meningitis (1), and anoxic encephalopathy (1). In two other positive patients, the dementia could not be confidently classified. Sensitivity, specificity, and negative predi ctive value were fairly good, but positive predictive value was poor. Similar results were found independently of the disease duration. There was no correlation between intensity nor pattern of the 14-3-3 protein expression and diagnosis. The 14-3-3 te st is not valid for discriminating between Creutzfeldt-Jakob disease and non-Creutzfeldt-Jakob disease in unselected patients with dementia. Positive results are found in various degenerative and secondary, prion-unrelated dementias. |
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degenerative diseases of CNS
dementia
dementia,diagnostic evaluation of
dementia,screening for
Jakob-Creutzfeldt disease
misdiagnosis
neurologic disease
neurologic disease,diagnoses of
protein 14-3-3,cerebrospinal fluid
protein 14-3-3,cerebrospinal fluid,false positive
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